• Sun. May 26th, 2024

Deciphering the Role of X Chromosomes in Autoimmune Diseases: Why Women are More Susceptible and How Early Diagnosis Can Make a Difference

BySamantha Nguyen

Mar 27, 2024
Women are more frequently affected by autoimmune diseases

In the 21st century, one in five people is affected by an autoimmune disease, which includes conditions such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and thyroiditis. These diseases occur when the immune system mistakenly attacks its own tissues, leading to tissue destruction due to an inflammatory reaction. The prevalence of autoimmune diseases has increased due to advancements in diagnostics and an increase in the average age of the population. Western lifestyles and environmental changes are also believed to contribute to the rise of these diseases.

Autoimmune diseases typically begin in middle age and affect up to 80 percent of those affected are women. Research led by Stanford University’s Diana Down confirms that women’s susceptibility to autoimmune attacks may be linked to mechanisms on the X chromosome. Specifically, researchers found that the silencing of one of the X chromosomes in women may incite autoimmune attacks. Animal studies using male mice showed that disrupting the xist protein strands led to more severe autoimmune responses, producing more autoantibodies and causing more tissue destruction in the presence of an autoimmune disease.

Understanding the role of xist protein strands in autoimmune diseases can lead to early identification through autoantibody testing. Autoantibodies are often present before symptoms of autoimmune diseases become apparent, making them valuable markers for diagnosis. This research highlights the importance of studying autoimmune diseases in both men and women to fully understand the underlying mechanisms at play.

By Samantha Nguyen

As a content writer at newsqwe.com, I am passionate about crafting engaging and informative articles that captivate our audience. With a background in journalism and a keen eye for detail, I strive to deliver content that is not only well-researched but also adds value to our readers' lives. From breaking news stories to in-depth features, I take pride in my ability to tell compelling stories that resonate with our diverse audience. When I'm not typing away at my keyboard, you can find me exploring new cafes, practicing yoga, or getting lost in a good book. I am thrilled to be a part of the newsqwe.com team and look forward to sharing my love for writing with all of our readers.

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