• Tue. Apr 23rd, 2024

Double-Legged Mice: Scientists Create New 6-Limb Embryo in Portugal

BySamantha Nguyen

Apr 3, 2024
Creating a six-legged mouse for the first time

In Portugal, a team of scientists have successfully created a 6-legged mouse embryo with an extra pair of hind legs instead of external genitalia. Moisés Mallo, a biologist at the Gulbenkian Institute of Sciences in Oerias, Portugal, and his colleagues are studying the receptor protein Tgfbr1, which plays a crucial role in embryonic development.

The Tgfbr1 gene codes for transforming growth factor beta type 1 receptor, which is involved in cellular responses like cell growth and division. Mutations in this gene can increase the risk of skin cancer. The researchers discovered that inactivating the Tgfbr1 gene in mouse embryos led to the development of hind legs instead of external genitalia.

Furthermore, the team found that Tgfbr1 dictates whether structures develop into genitals or legs. This means that by inactivating the protein, it can alter the activity of other genes resulting in mice with extra legs and no external genitalia. The researchers plan to investigate how Tgfbr1 and related genes affect other systems such as cancer metastasis and whether similar processes occur in reptiles with double penises.

The embryos used in this study were collected from mice aged 3-6 months. The research team dissected them further without distinguishing between male and female embryos since their external genitalia do not differ. Further research will focus on understanding the broader implications of Tgfbr1 gene function in development and disease.

Overall, this groundbreaking study highlights the importance of understanding how proteins like Tgfbr1 regulate embryonic development and their potential impact on disease processes such as cancer metastasis.

By Samantha Nguyen

As a content writer at newsqwe.com, I am passionate about crafting engaging and informative articles that captivate our audience. With a background in journalism and a keen eye for detail, I strive to deliver content that is not only well-researched but also adds value to our readers' lives. From breaking news stories to in-depth features, I take pride in my ability to tell compelling stories that resonate with our diverse audience. When I'm not typing away at my keyboard, you can find me exploring new cafes, practicing yoga, or getting lost in a good book. I am thrilled to be a part of the newsqwe.com team and look forward to sharing my love for writing with all of our readers.

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