• Sat. Jun 3rd, 2023

FivepHusion Announces Strategic Collaboration with Treehill Partners and Syneos Overall health


May 26, 2023

Supporting FivepHusion’s International Improvement and Commercialization Method

SYDNEY, May perhaps 26, 2023 /PRNewswire/ — FivepHusion, an sophisticated clinical-stage biotechnology organization, right now announced its collaboration with Treehill Partners, a New York-primarily based strategic and monetary advisory firm specializing in healthcare sector transactions, and Syneos Health® (Nasdaq: SYNH), a top totally integrated biopharmaceutical options organization, to create and bring a novel, enhanced chemotherapeutic item to market place.

Treehill Partners will assistance FivepHusion with integrated enterprise improvement, operational, strategic and transactional experience. Syneos Overall health will assistance FivepHusion’s integrated clinical improvement and commercialization capabilities. This collaboration is developed to strategically and optimally progress improvement and commercialization of FivepHusion’s enhanced chemotherapeutic formulation Deflexifol™ in worldwide markets.

“This is a extremely thrilling time for FivepHusion. We are at a vital stage in our development tactic. By collaborating with Treehill Partners and Syneos Overall health, we think we are positioned to effectively bring our improvement function on Deflexifol™ to worldwide markets, such as in the US, Europe and Asia,” mentioned Dr. Christian Toouli, CEO &amp Managing Director, FivepHusion. “This collaboration represents a distinctive functioning model to the sector. By way of the combined strength and competency of 3 sector leaders, we intend to maximize our progress on the improvement of Deflexifol™ and promptly bring revolutionary oncology medicines to individuals in have to have.”

“We’re excited to collaborate with FivepHusion and Treehill Partners to aid bring Deflexifol™ to individuals,” mentioned Christian Tucat, Chief Enterprise Officer, Syneos Overall health. “Leveraging our deep therapeutic and worldwide experience, Syneos Overall health is pleased to contribute to accelerating the clinical improvement and commercialization of this essential new therapy.”

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“This collaboration represents a new model of integrated solutions across disciplines, developed to let US and non-US emerging players to play a essential part on the worldwide stage, and we’re proud to function alongside FivepHusion and Syneos Overall health,” mentioned Ali Pashazadeh, Companion &amp Co-founder, Treehill Partners. “By merging the scientific prowess of our consumers with the clinical and industrial experience of Syneos Overall health and Treehill’s healthcare advisory and execution capabilities, we are delivering a distinctive ecosystem developed to aid corporations to flourish in spite of the existing difficult market place atmosphere.”

About FivepHusion

FivepHusion (www.fivephusion.com) is an sophisticated clinical-stage, globally focused biotechnology organization whose goal is to optimize chemotherapy to increase patient therapy outcomes and top quality of life.

FivepHusion is establishing Deflexifol™, a proprietary, novel, and optimized physiological pH formulation to co-administer the chemotherapeutic agent five-fluorouracil (five-FU) and its biomodulator leucovorin (LV), a drug that enhances five-FU anti-cancer activity. These drugs are normally made use of globally to treat numerous strong tumors such as colorectal, pancreatic, gastric and breast cancers. Nonetheless, due to their chemical incompatibility, existing formulations of five-FU and LV endure from limitations in their security, tolerability, effectiveness and pharmacological compatibility. These disadvantages contribute to restricted therapy response prices, unpleasant side effects and toxicities, and a decreased top quality of life knowledgeable by cancer individuals. Deflexifol™ has been developed to address these limitations via co-administration of the two agents with clinically demonstrated improvements in security and tolerability and the prospective to present superior anti-tumor efficacy, greater top quality of life, and all round enhanced clinical advantage for cancer individuals.

FivepHusion is establishing Deflexifol™ by way of the FDA 505(b)(two) and EMA Short article 10b regulatory pathways as a bioequivalent, chemotherapy replacement of sub-optimal normal of care formulations of five-FU and LV for the therapy of metastatic colorectal cancer, and other tumors with a projected worldwide incidence of higher than six million individuals. Deflexifol™ is also getting created as a new therapy for cancers with higher unmet healthcare have to have, such as pediatric ependymoma a uncommon and deadly brain cancer which afflicts extremely young kids.

Deflexifol™ is a trademark of FivepHusion.

About Syneos Overall health

Syneos Health® (Nasdaq: SYNH) is a top totally integrated biopharmaceutical options organization constructed to accelerate client results.  Syneos translates distinctive clinical, healthcare affairs and industrial insights into outcomes to address contemporary market place realities.

Syneos brings with each other a talented group of pros, who function across extra than 110 nations, with a deep understanding of patient and doctor behaviors and market place dynamics. Collectively Syneos shares insights, utilizes the newest technologies and applies sophisticated enterprise practices to speed customers’ delivery of essential therapies to individuals.

Syneos Overall health supports a diverse, equitable and inclusive culture that cares for colleagues, consumers, individuals, communities and the atmosphere.

To find out extra about how Syneos are Shortening the distance from lab to life®, stop by syneoshealth.com or subscribe to our podcast.

About Treehill Partners

Treehill was founded in 2014 and is led by companion and co-founder Ali Pashazadeh, who previously headed Blackstone’s healthcare advisory group and UBS’ European biotech coverage.

Treehill supports consumers in the healthcare sector all through the asset lifecycle, from acquire-side acquisition and investment more than worth develop and development to sell-side disposal and divestment. Important places of concentrate are the identifying and executing of worth inventive transactions and their knitting into productive corporate evolution techniques.

In delivering its guidance, the firm employs a multidisciplinary senior group with impeccable pedigree that comprises healthcare physicians/ MDs, scientists/ PhDs, CEOs of biotechs, senior executives from significant pharma, and knowledgeable tactic consultants and investment bankers. Solutions offered are centered about the “principal mentality” of the group, delivering actionable strategic and transaction guidance that matters to CEOs, senior leadership, their stakeholders and investors.



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