• Wed. May 29th, 2024

Revolutionizing Gene Therapy Manufacturing: Viralgen’s Pro10™ Technology for Scalable and Efficient rAAV Production

BySamantha Nguyen

Mar 27, 2024
A Unique Mammalian Suspension Technology Enhances Scalable rAAV Production with Pro10 Cell Line

Viralgen has developed a new technology, the Pro10™ cell line, to improve the efficiency and scalability of recombinant adeno-associated virus (rAAV) production for gene therapy manufacturing. This proprietary mammalian suspension technology allows for robust and scalable production of rAAVs, addressing the challenges faced in large-scale manufacturing in AAV gene therapies. The Pro10™ cells have been fully characterized and licensed for gene therapy development by other biopharma companies.

The Pro10™ cells are used as the foundation for Viralgen’s platform process for manufacturing AAV vectors. They have been optimized for rAAV production and successfully scaled up to 2000L, demonstrating consistent and reproducible cell growth rates. The cells exhibit similar productivity in small and large-scale bioreactors and can produce different AAV serotypes. The HEK293 derived animal component-free suspension Pro10™ cell line is described in full in the PDF, which highlights its ability to reduce process development time and costs.

This innovative technology is a promising advancement in the field of gene therapy manufacturing, offering a solution to the challenges faced in large-scale production of AAV vectors. Viralgen’s use of this technology has played a crucial role in producing groundbreaking gene therapies, and it has the potential to revolutionize the field of gene therapy manufacturing.

By Samantha Nguyen

As a content writer at newsqwe.com, I am passionate about crafting engaging and informative articles that captivate our audience. With a background in journalism and a keen eye for detail, I strive to deliver content that is not only well-researched but also adds value to our readers' lives. From breaking news stories to in-depth features, I take pride in my ability to tell compelling stories that resonate with our diverse audience. When I'm not typing away at my keyboard, you can find me exploring new cafes, practicing yoga, or getting lost in a good book. I am thrilled to be a part of the newsqwe.com team and look forward to sharing my love for writing with all of our readers.

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